Too much fuel, 25 pilots + 2.75 on the screws is too much fuel on the bottom end. Add that to a needle on the 4th clip and you're fat all the way through low range and a good bit into mid. Unless you've got an airleak somewhere, you're likely too rich.
Try backing down to 1 on the fuel screws and move up from there. You can start with the needle on whatever clip you have it on now, and if doesn't work switch to the 3rd/4th (whichever one you didn't start on) and try it again.
For future reference the screws are fuel screws, not necessarily mixture or a/f screws. Turning them in decreases fuel provided, turning them out increases fuel provided.